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Article

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.

Human molecular genetics - 1 Mar 2015

Johnson William M, Yao Chen, Siedlak Sandra L, Wang Wenzhang, Zhu Xiongwei, Caldwell Guy A, Wilson-Delfosse Amy L, Mieyal John J, Chen Shu G

Abstract excerpt

Parkinson's disease (PD) is characterized by selective degeneration of dopaminergic neurons. Although the etiology of PD remains incompletely understood, oxidative stress has been implicated as an important contributor in the development of PD. Oxidative stress can lead to oxidation and functional perturbation of proteins critical to neuronal survival. Glutaredoxin 1 (Grx1) is an evolutionally conserved...

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PMID: 25355420
DOI: 10.1093/hmg/ddu542
PMCID: PMC4321441

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