Article

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s disease

2020-07-06

Abstract excerpt

<h4>Background</h4> Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most frequent cause of late-onset, familial Parkinson’s disease (PD), and LRRK2 variants are associated with increased risk for sporadic PD. While advanced age represents the strongest risk factor for disease development, it remains unclear how different age-related pathways interact to regulate LRRK2 -driven late-onset P...

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Literature Corpus work: 778f3720-e1f9-5fb0-bb64-6c65ed565411
DOI: 10.1101/2020.07.06.190025

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