Article
Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice.
Molecular neurobiology - 1 Apr 2021
Obrador Elena, Salvador Rosario, Marchio Patricia, López-Blanch Rafael, Jihad-Jebbar Ali, Rivera Pilar, Vallés Soraya L, Banacloche Salvador, Alcácer Javier, Colomer Nuria, Coronado Javier A, Alandes Sandra, Drehmer Eraci, Benlloch María, Estrela José M
Abstract excerpt
Oxidative stress-induced damage is a major mechanism in the pathophysiology of amyotrophic lateral sclerosis (ALS). A recent human clinical trial showed that the combination of nicotinamide riboside (NR) and pterostilbene (PT), molecules with potential to interfere in that mechanism, was efficacious in ALS patients. We examined the effect of these molecules in SOD1G93A transgenic mice, a well-stablished model of...
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