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Article

Systemic characterization of aging-related phenotypes induced by wild-type and G2019S LRRK2 in Caenorhabditis elegans.

Experimental neurology - 1 Oct 2026

Li Chun, Shi Fu-Yi, He Xuan-Xuan, Xiong Shi-Ying, Gu Long, Wu Gui-Sheng, Hou Pan-Pan, Huang Chen, Luo Huai-Rong

Abstract excerpt

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2), initially identified as a gene implicated in Parkinson's disease, is increasingly recognized for its influence on aging and associated disorders. However, its systemic roles in biological aging remain poorly understood. METHODS: To assess its physiological roles, we utilized Caenorhabditis elegans models with pan-neuronal expression of either wild-type or...

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PMID: 42270006
DOI: 10.1016/j.expneurol.2026.115873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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