Article

NAMPT deficiency triggers dopaminergic neurodegeneration in the substantia nigra of mouse

2024-03-06

Abstract excerpt

<title>Abstract</title> <p>Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme in the salvaging synthesize pathway of nicotinamide adenine dinucleotide (NAD). The neuroprotective roles of NAMPT on neurodegeneration have been widely explored in aging brain and Alzheimer’s Disease. However, its roles in Parkinson’s Disease (PD) remain to be elucidated. We found that the dopaminergic neurons in substant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 386c8682-04b3-5e0b-92c7-c508e9b30958
DOI: 10.21203/rs.3.rs-3993436/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NAMPT deficiency triggers dopaminergic neurodegeneration in the substantia nigra of mouseDOI 10.21203/rs.3.rs-3993436/v1Read

The NAD <sup>+</sup> precursor NMN activates dSarm to trigger axon degeneration in <i>Drosophila</i>Semantic proximity Read

Research advances in the function and anti-aging effects of nicotinamide mononucleotideSemantic proximity Read

Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson’s ModelSemantic proximity Read

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageingSemantic proximity Read

NAD and axon degeneration: From the Wlds gene to neurochemistrySemantic proximity Read

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.Semantic proximity Read

Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide PhosphoribosyltransferaseSemantic proximity Read

In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expressionSemantic proximity Read

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in CancerSemantic proximity Read

Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neuronsSemantic proximity Read

Nicotinamide riboside alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failureSemantic proximity Read

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal BrainSemantic proximity Read