Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unraveling Parkinson’s Disease Neurodegeneration: Does Aging Hold the Clues?

21 Oct 2022

Abstract excerpt

Aging is the greatest risk factor for Parkinson's disease (PD), suggesting that mechanisms driving the aging process promote PD neurodegeneration. Several lines of evidence support a role for aging in PD. First, hallmarks of brain aging such as mitochondrial dysfunction and oxidative stress, loss of protein homeostasis, and neuroinflammation are centrally implicated in PD development. Second, mutations that cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36278358
DOI: 10.3233/jpd-223363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unraveling Parkinson’s Disease Neurodegeneration: Does Aging Hold the Clues?PMID 36278358Read ↗

Aging, cellular senescence and Parkinson's diseaseSemantic proximity Read ↗

The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s DiseaseSemantic proximity Read ↗

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's diseaseSemantic proximity Read ↗

Is age-related failure of metabolic reprogramming a principal mediator in idiopathic Parkinson's disease? Implications for treatment and inverse cancer risk.Semantic proximity Read ↗

LRRK2 at the Crossroad of Aging and Parkinson's Disease.Semantic proximity Read ↗

Brain Mitochondria, Aging, and Parkinson’s DiseaseSemantic proximity Read ↗

Is Parkinson's really a disease? Reframing it as a phenotype of aging.Semantic proximity Read ↗

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalkSemantic proximity Read ↗

Metabolic Mechanisms Connecting Alzheimer’s and Parkinson’s Diseases: Potential Avenues for Novel Therapeutic ApproachesSemantic proximity Read ↗

Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell deathSemantic proximity Read ↗

Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and NeurodegenerationSemantic proximity Read ↗

Omics data integration suggests a potential idiopathic Parkinson’s disease signatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.