Article

Bile Acid Scaffold Engineering Reveals an Androstane-Triol Derivative as a Potent Immunomodulator with Therapeutic Efficacy in EAE

2026-01-05

Abstract excerpt

<h4>Background</h4> Neuroinflammation driven by dysregulated adaptive and innate immune responses plays a central role in the pathogenesis of multiple sclerosis and related autoimmune disorders of the central nervous system. While bile acids are increasingly recognized as endogenous immunomodulators, their therapeutic exploitation has been limited by modest potency and incomplete mechanistic understanding. Here,...

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Literature Corpus work: e54344dc-3b73-5921-b9ab-b2183b35d3c3
DOI: 10.64898/2026.01.05.697637

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