Article

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

2019-05-07

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including the CNS and immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, we identified lower levels of circulating bile acid metabolites in multiple cohorts of adul...

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Literature Corpus work: d037f2e2-1a7e-5dd8-afaa-5ede570d05b4
DOI: 10.1101/627356

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