Article
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.
Journal of autoimmunity - 1 Apr 2024
Wørzner Katharina, Zimmermann Julie, Buhl Regitze, Desoi Anna, Christensen Dennis, Dietrich Jes, Nguyen Nina Dieu Nhien Tran, Lindenstrøm Thomas, Woodworth Joshua S, Alhakeem Reham Sabah, Yu Steven, Ødum Niels, Mortensen Rasmus, Ashouri Judith F, Pedersen Gabriel K
Abstract excerpt
In many autoimmune diseases, autoantigen-specific Th17 cells play a pivotal role in disease pathogenesis. Th17 cells can transdifferentiate into other T cell subsets in inflammatory conditions, however, there have been no attempts to target Th17 cell plasticity using vaccines. We investigated if autoantigen-specific Th17 cells could be specifically targeted using a therapeutic vaccine approach, where antigen was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.