Article

Drug library screen identifies inhibitors of toxic astrogliosis

2020-09-18

Abstract excerpt

<h4>Objective</h4> Multiple sclerosis is a chronic neuroinflammatory disorder, in which activated immune cells directly or indirectly induce demyelination and axonal degradation. Inflammatory stimuli also change the phenotype of astrocytes, making them neurotoxic. The resulting ‘toxic astrocyte’ phenotype has been observed in animal models of neuroinflammation and in multiple sclerosis lesions. Proteins secreted b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 855c1b21-817b-5d9a-a330-494eb750aff9
DOI: 10.1101/2020.09.15.20195016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug library screen identifies inhibitors of toxic astrogliosisDOI 10.1101/2020.09.15.20195016Read

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytesSemantic proximity Read

Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies.Semantic proximity Read

Identification of repurposable cytoprotective drugs for Vanishing White Matter DiseaseSemantic proximity Read

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signalingSemantic proximity Read

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read

Identification of Repurposable Cytoprotective Drugs in Vanishing White Matter Disease Patient-Derived cellsSemantic proximity Read

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic PotentialSemantic proximity Read

Chemical inhibition of pathological reactive astrocytes promotes neural protectionSemantic proximity Read

ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulationSemantic proximity Read

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.Semantic proximity Read

Reactive Glia-Derived Neuroinflammation: a Novel Hallmark in Lafora Progressive Myoclonus Epilepsy That Progresses with AgeSemantic proximity Read

Identification of repurposable cytoprotective drugs in Vanishing White Matter Disease patient-derived cellsSemantic proximity Read