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Article

Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination.

Biomolecules - 24 Aug 2020

Moreno-García Álvaro, Bernal-Chico Ana, Colomer Teresa, Rodríguez-Antigüedad Alfredo, Matute Carlos, Mato Susana

Abstract excerpt

The endocannabinoid system is associated with protective effects in multiple sclerosis (MS) that involve attenuated innate immune cell responses. Astrocytes and microglia are modulated by endocannabinoids and participate in the biosynthesis and metabolism of these compounds. However, the role of neuroglial cells as targets and mediators of endocannabinoid signaling in MS is poorly understood. Here we used a...

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Identifiers

PMID: 32846891
DOI: 10.3390/biom10091228
PMCID: PMC7563448

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