Article

Treatment with an Antigen-Specific Dual Microparticle System Reverses Advanced Multiple Sclerosis in Mice

2022-03-27

Abstract excerpt

Antigen-specific therapies hold promise for treating autoimmune diseases such as multiple sclerosis while avoiding the deleterious side effects of systemic immune suppression. In this study, an antigen-specific dual-sized microparticle (dMP) immunotherapy reversed hind limb paralysis when administered in mice with advanced experimental autoimmune encephalomyelitis (EAE). Treatment reduced central nervous system (C...

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Literature Corpus work: e465ec6c-9028-5fbd-bec1-96f5d94e0bbc
DOI: 10.1101/2022.03.25.485841

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