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Article

Genetic trade-offs between complex diseases and longevity.

Aging cell - 1 Jul 2022

Hu Dingxue, Li Yan, Zhang Detao, Ding Jiahong, Song Zijun, Min Junxia, Zeng Yi, Nie Chao

Abstract excerpt

Longevity was influenced by many complex diseases and traits. However, the relationships between human longevity and genetic risks of complex diseases were not broadly studied. Here, we constructed polygenic risk scores (PRSs) for 225 complex diseases/traits and evaluated their relationships with human longevity in a cohort with 2178 centenarians and 2299 middle-aged individuals. Lower genetic risks of stroke and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35754110
DOI: 10.1111/acel.13654
PMCID: PMC9282840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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