Article

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

2020-08-03

Abstract excerpt

αSynuclein aggregation at the synapse is an early event in Parkinson’s disease and is associated with impaired striatal synaptic function and dopaminergic neuronal death. The cysteine string protein (CSPα) and αsynuclein have partially overlapping roles in maintaining synaptic function and mutations in each cause neurodegenerative diseases. CSPα is a member of the DNAJ/HSP40 family of co-chaperones and like αsynuc...

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Literature Corpus work: d6d3075a-3ff0-5ebd-95c7-213416527213
DOI: 10.1101/2020.07.31.229153

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