Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.

doi:10.1080/15548627.2016.1214777

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Article

Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats.

Autophagy - 1 Nov 2016

Xilouri Maria, Brekk Oeystein Roed, Polissidis Alexia, Chrysanthou-Piterou Margarita, Kloukina Ismini, Stefanis Leonidas

Abstract excerpt

Chaperone-mediated autophagy (CMA) involves the selective lysosomal degradation of cytosolic proteins such as SNCA (synuclein α), a protein strongly implicated in Parkinson disease (PD) pathogenesis. However, the physiological role of CMA and the consequences of CMA failure in the living brain remain elusive. Here we show that CMA inhibition in the adult rat substantia nigra via adeno-associated virus-mediated...

Topics

Animals
Autophagy
Behavior, Animal
Dependovirus
Dopaminergic Neurons
Down-Regulation
Female
Gene Silencing
Genetic Vectors
Lysosomal-Associated Membrane Protein 2
Molecular Chaperones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neostriatum

Nerve Degeneration

Phenotype

RNA, Small Interfering

Rats, Wistar

Sequestosome-1 Protein

Substantia Nigra

Source

Open in PubMed Open full text

Identifiers

PMID: 27541985
DOI: 10.1080/15548627.2016.1214777
PMCID: PMC5103347

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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