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Article

alpha-synuclein and Parkinson's disease: the first roadblock.

Journal of cellular and molecular medicine - 1 Jan 2000

Chua Christelle En Lin, Tang Bor Luen

Abstract excerpt

alpha-synuclein gene mutations are major underlying genetic defects known in familial juvenile onset Parkinson's disease (PD), and alpha-synuclein is a major constituent of Lewy Bodies, the pathological hallmark of PD. The normal cellular function of alpha-synuclein has been elusive, and its exact etiological mechanism in causing dopaminergic neuronal death in PD is also not clearly understood. Very recent...

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Identifiers

PMID: 17125588
DOI: 10.1111/j.1582-4934.2006.tb00528.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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