Article

Secreted cytokines provide local immune tolerance for human stem cell-derived islets

2022-05-10

Abstract excerpt

<h4>Summary</h4> Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches to produce hypoimmunogenic SC-islet cells have so far shown variable results. Here, we show that targeting the human leukocyte antigens (HLAs) and PD-L1 alone do not sufficiently protect SC-islet cells f...

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Literature Corpus work: e53a103e-dad2-51fc-93da-0807ed3f4cf4
DOI: 10.1101/2022.05.09.487072

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