Article
Localized immunomodulation with cytokine-producing cells to mitigate host immune rejection responses in rodents and a non-human primate
2025-10-15
Abstract excerpt
The efficacy of cell-based therapeutics is often compromised by host immune recognition of implanted cells and biomaterials, resulting in fibrotic encapsulation and loss of function. Here, we address this challenge with an immunomodulatory cell-based therapy, in which alginate-encapsulated retinal pigment epithelial cells continuously secrete cytokines to locally modulate the implant microenvironment. In a healthy...
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Identifiers and source
- Literature Corpus work
- 1af666ef-5fa6-5a4d-bd96-3b48bea02b95
- DOI
- 10.1101/2025.10.13.682221