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iPSC modification strategies to induce immune tolerance

30 Mar 2025

Abstract excerpt

Human pluripotent stem cells (hPSCs) hold great promise in regenerative medicine. However, immune rejections remain one of the major obstacles to stem cell therapy. Though conventional immunosuppressants are available in clinics, the side effects prevent the wide application of hPSCs derivatives, compromising both survival rate and quality of life. In recent years, a myriad of strategies aimed at inducing immune...

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PMID: 40376110
DOI: 10.1093/lifemedi/lnaf016

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