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Article

Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.

Cell reports - 17 Aug 2021

Parent Audrey V, Faleo Gaetano, Chavez Jessica, Saxton Michael, Berrios David I, Kerper Natanya R, Tang Qizhi, Hebrok Matthias

Abstract excerpt

Stem cell-based replacement therapies hold the promise to restore function of damaged or degenerated tissue such as the pancreatic islets in people with type 1 diabetes. Wide application of these therapies requires overcoming the fundamental roadblock of immune rejection. To address this issue, we use genetic engineering to create human pluripotent stem cells (hPSCs) in which the majority of the polymorphic human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34407395
DOI: 10.1016/j.celrep.2021.109538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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