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Article

Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets

1 Sept 2022

Abstract excerpt

Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC-islets) can be produced by directed differentiation. However, preventing allo-rejection and recurring autoimmunity, without the use of encapsulation or systemic immunosuppressants, remains a challenge. An attractive approach is to...

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PMID: 36055241
DOI: 10.1016/j.stemcr.2022.08.002

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