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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

1 Jan 2023

Abstract excerpt

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be achieved without chronic immunosuppression or encapsulation. Existing genetic engineering approaches to produce immune-evasive SC-islet cells have so far shown variable results. Here, we show that targeting human leukocyte antigens (HLAs) and PD-L1 alone does not sufficiently protect SC-islet cells from xenograft...

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PMID: 36599351
DOI: 10.1016/j.xcrm.2022.100879

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