Article

Multi-predictor pathogenicity filtering and membrane-specific stability analysis identify and characterize candidate destabilizing missense variants of the GIP receptor (GIPR)

2026-06-29

Abstract excerpt

<title>Abstract</title> <p>The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a class B G protein-coupled receptor and a validated target of incretin-based therapies for type 2 diabetes and obesity, yet the functional consequences of its missense variation remain largely uncharacterized. Because most variant-effect and stability predictors were developed for soluble, globular proteins and transfe...

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Literature Corpus work: 49f2bfb9-b219-5120-94e2-8f83c56f6c9e
DOI: 10.21203/rs.3.rs-10159812/v1

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