Article

<i>In vivo</i> functional profiling and structural characterisation of the human <i>Glp1r</i> A316T variant

2024-10-21

Abstract excerpt

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective therapies for type 2 diabetes (T2D) and obesity, yet patient responses are variable. Variation in the human Glp1r gene might be directly linked to therapeutic responses. A naturally occurring missense variant, A316T, protects against T2D and cardiovascular disease. Here, we have generated and characterised a human Glp1r A316T mouse model. Human...

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Literature Corpus work: e291085a-b7ea-50d2-a03f-52909254052f
DOI: 10.1101/2024.10.19.619191

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