Article

Human GLP1R variants affecting GLP1R cell surface expression contribute to impaired glucose control and increased adiposity

2022-11-07

Abstract excerpt

<title>Abstract</title> The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists being prescribed in patients with type 2 diabetes (T2D) and obesity. The impact of genetic variability of the <italic>GLP1R </italic>gene on receptor function and its association with metabolic traits are unclear. Here, functional profiling of 59 rare and one common <italic>GLP1R </italic>variant a...

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Literature Corpus work: 4606fbf7-dd52-5d61-b1c7-7796d3367906
DOI: 10.21203/rs.3.rs-2114208/v1

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