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Article

High-throughput functional evaluation of human cancer-associated mutations using base editors.

Nature biotechnology - 1 Jun 2022

Kim Younggwang, Lee Seungho, Cho Soohyuk, Park Jinman, Chae Dongwoo, Park Taeyoung, Minna John D, Kim Hyongbum Henry

Abstract excerpt

Comprehensive phenotypic characterization of the many mutations found in cancer tissues is one of the biggest challenges in cancer genomics. In this study, we evaluated the functional effects of 29,060 cancer-related transition mutations that result in protein variants on the survival and proliferation of non-tumorigenic lung cells using cytosine and adenine base editors and single guide RNA (sgRNA) libraries. By...

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Identifiers

PMID: 35411116
DOI: 10.1038/s41587-022-01276-4
PMCID: PMC10243181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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