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Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target

2025-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type specific mRNA sequencing to profile molecular alterations of cortical excitatory and inhibitory neurons in Fmr1 knockout (KO) mice, integrating transcriptomic results with circuit and behavioral r...

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Literature Corpus work
e4fe20de-23a5-57db-87a6-c03821ba75f9
DOI
10.1101/2025.04.21.649817
Open publication

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Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic targetDOI 10.1101/2025.04.21.649817
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