Article

<i>FMR1</i> gene therapy restores activity-driven inhibition and prevents audiogenic seizures in <i> Fmr1 <sup>-/y</sup> </i> mice

2026-06-16

Abstract excerpt

<h4>Summary</h4> Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with auditory hypersensitivity, circuit hyperexcitability, and seizures. Whether re-expression of the FMR1 gene and encoded Fragile X Messenger Ribonucleoprotein (FMRP) can restore sensory circuit dysfunction remains unclear. Here, we show that a viral AAV- FMR1 vector rescues audiogenic seizures in the Fmr1 ⁻/y mouse model...

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Literature Corpus work: aa35d8bb-7f31-5cc0-bf92-91b353c7ebcf
DOI: 10.64898/2026.06.12.731901

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