Article

<i>FMR1</i> reduction alters cellular and circuit properties in human cortex

2026-03-12

Abstract excerpt

Transcriptional silencing of FMR1 results in Fragile X syndrome (FXS), the leading inherited cause of intellectual disability (ID) and autism. The Fmr1 -/y mouse model has been used to identify FXS disease mechanisms, whereas mechanistic insights from human brain are lacking. By leveraging organotypic human cortical slices and viral tools to reduce FMR1 expression, we create a new model that captures cell type-...

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Literature Corpus work: b886e2d8-e801-5c5a-8e3c-64e3a887716a
DOI: 10.64898/2026.03.11.711123

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