Article

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types

2019-09-09

Abstract excerpt

<h4>Summary</h4> Loss of function of the Fragile X Mental Retardation Protein (FMRP) in human Fragile X Syndrome (FXS) and in model organisms results in phenotypes of abnormal neuronal structure and dynamics, synaptic function and connectivity which may contribute to a state of neuronal, circuit and organism hyperexcitability. Previous in vivo identification of FMRP association with specific mRNA targets in mous...

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Literature Corpus work: fd7cf045-8e09-50d6-a88a-47f31721cb0d
DOI: 10.1101/762500

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