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Transcriptional dysregulation and impaired neuronal activity in <i>FMR1</i> knock-out and Fragile X patients’ iPSC-derived models

2023-08-31

Abstract excerpt

The lack of fragile X mental retardation protein (FMRP) protein, due to a repression of the FMR1 gene, causes Fragile X syndrome (FXS), one of the most prevalent forms of syndromic autisms. The FMR1 gene codes for an RNA binding protein involved in the regulation of gene expression through RNA processing, control of local translation, and protein-protein interactions; processes that are crucial for proper brain...

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Literature Corpus work
a821bf48-371f-5c9a-83d3-9d4783283f2c
DOI
10.1101/2023.08.30.554628
Open publication

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Transcriptional dysregulation and impaired neuronal activity in <i>FMR1</i> knock-out and Fragile X patients’ iPSC-derived modelsDOI 10.1101/2023.08.30.554628
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