Article

Fragile X syndrome patient-derived neurons developing in the mouse brain show <i>FMR1</i> -dependent phenotypes

2021-09-28

Abstract excerpt

Abnormal neuronal development in Fragile X syndrome (FXS) is poorly understood. Data on FXS patients remain scarce and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology and function of human neurons. Here, we co-injected neural precursor cells (NPCs) from FXS patient-derived and corrected isogenic control induced pluripotent stem cells into the b...

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Literature Corpus work: 407093db-6016-5a13-a3bf-19f63f51bda9
DOI: 10.1101/2021.09.27.461739

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