Article

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse model

2025-09-17

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination, axonal injury, and neurodegeneration. Smoldering lesions— defined by an inactive core, poor remyelination, and a rim of chronically activated microglia— are hallmarks of a progressive disease course and correlate with irreversible disability. The mechanisms driving their formation remain poorly u...

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Literature Corpus work: e4d9fb80-44e5-5bf0-a8cf-73f67bc9cb11
DOI: 10.1101/2025.09.16.676229

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