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Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions

5 Nov 2024

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compartmentalized and restricted to specific tissue niches such as the lesion rim. However, the precise cell type composition of such niches, their interactions and changes between chronic active and inactive stages are incompletely understood. We used single-nucleus and spatial transcriptomics from...

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PMID: 39501036
DOI: 10.1038/s41593-024-01796-z

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