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Article

Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis.

Acta neuropathologica - 25 Jun 2026

Lütje Lukas, Chen J Q Alida, Hamann Jörg, Smolders Joost, Huitinga Inge, van den Bosch Aletta M R

Abstract excerpt

Multiple sclerosis (MS) shows pronounced pathological and clinical variability between individuals, reflecting differences in genetic susceptibility, inflammatory activity, and tissue repair. This variability complicates efforts to relate lesion pathology to clinical trajectories. In previous work in the Netherlands Brain Bank MS autopsy cohort (NBB-MS), we showed that relative proportions of different lesion...

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Identifiers

PMID: 42350827
DOI: 10.1007/s00401-026-03040-3
PMCID: PMC13303759

Genes

DYSF
ZNF638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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