Article

Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche

2024-08-16

Abstract excerpt

Dendritic cell (DC) homeostasis is maintained in secondary lymphoid organs (SLOs) by Fms-like tyrosine kinase 3 ligand (FLT3L). The specific niche providing this DC growth factor within human and mouse SLOs is unclear. Here, we show that Gremlin1 (Grem1)-expressing lymph node fibroblastic reticular cells (FRCs) support DC homeostasis via provision of FLT3L. Grem1 FRCs co-localize with DCs and express FLT3L in huma...

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Identifiers and source

Literature Corpus work: e4d7cc87-ede6-56eb-b997-cd369144ab7a
DOI: 10.1101/2024.08.12.607692

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