Article
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.
The Journal of experimental medicine - 20 Oct 2014
Fasnacht Nicolas, Huang Hsin-Ying, Koch Ute, Favre Stéphanie, Auderset Floriane, Chai Qian, Onder Lucas, Kallert Sandra, Pinschewer Daniel D, MacDonald H Robson, Tacchini-Cottier Fabienne, Ludewig Burkhard, Luther Sanjiv A, Radtke Freddy
Abstract excerpt
Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-mediated lineage...
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