Article

Engineered niches support the development of human dendritic cells in humanized mice

2019-11-08

Abstract excerpt

Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is both crucial to study cDCs and harness their potential in immunotherapy. Here we addressed whether cDCs could differentiate in response to trophic cues delivered by mesenchymal components of the hematopoietic niche where they physiologically develop and maintain. We found that ex...

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Literature Corpus work: b1258ff5-e793-5526-85ab-a80a0f29ebe5
DOI: 10.1101/835223

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