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Article

Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.

Nature immunology - 1 Apr 2021

Prados Alejandro, Onder Lucas, Cheng Hung-Wei, Mörbe Urs, Lütge Mechthild, Gil-Cruz Cristina, Perez-Shibayama Christian, Koliaraki Vasiliki, Ludewig Burkhard, Kollias George

Abstract excerpt

Fibroblastic reticular cells (FRCs) determine the organization of lymphoid organs and control immune cell interactions. While the cellular and molecular mechanisms underlying FRC differentiation in lymph nodes and the splenic white pulp have been elaborated to some extent, in Peyer's patches (PPs) they remain elusive. Using a combination of single-cell transcriptomics and cell fate mapping in advanced mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33707780
DOI: 10.1038/s41590-021-00894-5
PMCID: PMC7610542

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