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Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer

19 Nov 2024

Abstract excerpt

Stringent control of T cell activity in the tumor microenvironment is essential for the generation of protective antitumor immunity. However, the identity, differentiation, and functions of the cells that create critical fibroblastic niches promoting tumor-infiltrating T cells remain elusive. Here, we show that CCL19-expressing fibroblastic reticular cells (FRCs) generate interconnected T cell environments (TEs)...

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PMID: 39566495
DOI: 10.1016/j.cell.2024.10.042

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