Article

DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies

2024-12-03

Abstract excerpt

Primary myelofibrosis (PMF) is a clonal blood disorder characterized by mutually exclusive driver mutations in JAK2 , CALR , or MPL genes. To explore the epigenetic impact of these mutations, we analyzed DNA methylation (DNAm) profiles from PMF patients. Notably, no differences were found in DNAm between JAK2 and CALR mutated cases, whereas MPL mutations displayed slightly distinct patterns. Furthermore, induced p...

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Literature Corpus work: e4d796ba-f63e-550d-ac52-81ce158bca23
DOI: 10.1101/2024.12.02.24318089

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