Article
Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations.
Scientific reports - 28 Jul 2017
Nielsen Helene Myrtue, Andersen Christen Lykkegaard, Westman Maj, Kristensen Lasse Sommer, Asmar Fazila, Kruse Torben Arvid, Thomassen Mads, Larsen Thomas Stauffer, Skov Vibe, Hansen Lise Lotte, Bjerrum Ole Weis, Hasselbalch Hans Carl, Punj Vasu, Grønbæk Kirsten
Abstract excerpt
This is the first study to compare genome-wide DNA methylation profiles of sorted blood cells from myelofibrosis (MF) patients and healthy controls. We found that differentially methylated CpG sites located to genes involved in 'cancer' and 'embryonic development' in MF CD34+ cells, in 'inflammatory disease' in MF mononuclear cells, and in 'immunological diseases' in MF granulocytes. Only few differentially...
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