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Article

The Genetic Basis of Primary Myelofibrosis and Its Clinical Relevance.

International journal of molecular sciences - 24 Nov 2020

Rumi Elisa, Trotti Chiara, Vanni Daniele, Casetti Ilaria Carola, Pietra Daniela, Sant'Antonio Emanuela

Abstract excerpt

Among classical BCR-ABL-negative myeloproliferative neoplasms (MPN), primary myelofibrosis (PMF) is the most aggressive subtype from a clinical standpoint, posing a great challenge to clinicians. Whilst the biological consequences of the three MPN driver gene mutations (JAK2, CALR, and MPL) have been well described, recent data has shed light on the complex and dynamic structure of PMF, that involves competing...

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Identifiers

PMID: 33255170
DOI: 10.3390/ijms21238885
PMCID: PMC7727658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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