[Molecularly pathogenesis and molecular targeted therapy for myeloproliferative neoplasms].

Abstract excerpt

Activation of the JAK-STAT pathway by driver mutations of JAK2, CALR or MPL is the pathogenesis of myeloproliferative neoplasms (MPN). Mutations in epigenetic regulators that often coexist with driver mutations reinforce the function of MPN initiating cells and support MPN onset and maintenance. In myelofibrosis patients, JAK2 inhibitors exerted an innovative therapeutic effect on splenomegaly and constitutional...

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