Identification of unique genetic and epigenetic signatures in myeloproliferative neoplasms using microarray and next generation sequencing : association with MPN-related mutations and clinical phenotypes

Abstract excerpt

The past decade has witnessed significant progress in the understanding of the molecular pathogenesis of myeloproliferative neoplasms (MPN). Mutations in a large number of genes have now been implicated in the pathogenesis of MPN but their relative importance, the mechanisms by which they cause different cells to predominate and differentiate into the separate MPN syndromes and their implications for prognosis rem...

Topics

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• Acute Myeloid Leukemia Research
• Chromosome Aberrations
• Kruppel-like factors research
• Mutation
• Myeloproliferative Disorders
• Myeloproliferative Neoplasms: Diagnosis and Treatment
• Neoplasms
• Primary Myelofibrosis

Identifiers and source

Literature Corpus work

6478cbc9-af93-5726-a3b5-a3a0b0d7a60a

DOI

10.25560/52714