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Article

Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2024

Kandarpa Malathi, Robinson Dan, Wu Yi-Mi, Qin Tingting, Pettit Kristen, Li Qing, Luker Gary, Sartor Maureen, Chinnaiyan Arul, Talpaz Moshe

Abstract excerpt

PURPOSE: Myeloproliferative neoplasms (MPN) are characterized by the overproduction of differentiated myeloid cells. Mutations in JAK2, CALR, and MPL are considered drivers of Bcr-Abl-ve MPN, including essential thrombocythemia (ET), polycythemia vera (PV), prefibrotic primary myelofibrosis (prePMF), and overt myelofibrosis (MF). However, how these driver mutations lead to phenotypically distinct and/or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38386293
DOI: 10.1158/1078-0432.CCR-23-0372
PMCID: PMC11061602

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