Article
Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms.
Cancer research - 1 Feb 2013
Nischal Sangeeta, Bhattacharyya Sanchari, Christopeit Maximilian, Yu Yiting, Zhou Li, Bhagat Tushar D, Sohal Davendra, Will Britta, Mo Yongkai, Suzuki Masako, Pardanani Animesh, McDevitt Michael, Maciejewski Jaroslaw P, Melnick Ari M, Greally John M, Steidl Ulrich, Moliterno Alison, Verma Amit
Abstract excerpt
Even though mutations in epigenetic regulators frequently occur in myeloproliferative neoplasms, their effects on the epigenome have not been well studied. Furthermore, even though primary myelofibrosis (PMF) has a markedly worse prognosis than essential thrombocytosis or polycythemia vera, the molecular distinctions between these subgroups are not well elucidated. We conducted the HELP (HpaII tiny fragment...
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