Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role and Impact of Non-driver Gene Mutations in Myelofibrosis.

Current hematologic malignancy reports - 10 Feb 2026

Boldrini Valentina, Guglielmelli Paola, Vannucchi Alessandro M

Abstract excerpt

PURPOSE OF THE REVIEW: Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional symptoms, bone marrow fibrosis and potential progression to a blast phase. This review provides a comprehensive overview of the current molecular landscape of MF beyond canonical driver mutations (JAK2, MPL or CALR), emphasizing insights gained from murine models that served as valuable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Primary Myelofibrosis
Share to CBL gene
Share to DNMT3A gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SF3B1 gene

Share to SRSF2 gene

Share to Genetic Predisposition to Disease

Share to Mutation

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41665690
DOI: 10.1007/s11899-026-00773-6
PMCID: PMC12891010

Genes

CALR
JAK2
MPL
ASXL1
CBL
DNMT3A
IDH1
IDH2
KRAS
NFE2
NRAS
RUNX1
SF3B1
SRSF2
TET2
TP53
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role and Impact of Non-driver Gene Mutations in Myelofibrosis.PMID 41665690Read ↗

Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment AdvancementsSemantic proximity Read ↗

Myeloproliferative Neoplasms: Contemporary Review and Molecular Landscape.Semantic proximity Read ↗

Exploring the Molecular Landscape of Myelofibrosis, with a Focus on Ras and Mitogen-Activated Protein (MAP) Kinase SignalingSemantic proximity Read ↗

Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations.Semantic proximity Read ↗

Molecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A Review.Semantic proximity Read ↗

Molecular findings in myeloid neoplasms.Semantic proximity Read ↗

Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape.Semantic proximity Read ↗

Myeloproliferative neoplasms: updates on molecular pathophysiology, diagnosis and treatment strategies.Semantic proximity Read ↗

Myeloid malignancies: mutations, models and management.Semantic proximity Read ↗

Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers.Semantic proximity Read ↗

Impact of molecular profiling on the management of patients with myelofibrosis.Semantic proximity Read ↗

Molecular Pathogenesis of Myeloproliferative Neoplasms: From Molecular Landscape to Therapeutic Implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.