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Article

Molecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A Review.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2016

Alshemmari Salem H, Rajan Reshmi, Emadi Ashkan

Abstract excerpt

Primary myelofibrosis (PMF) is a rare chronic BCR-ABL1-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional symptoms. The diagnosis is based on bone marrow...

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Source

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Identifiers

PMID: 27756071
DOI: 10.1159/000450956
PMCID: PMC5588514

Genes

CALR
ASXL1
JAK2
ABL1
BCR
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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