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Article

A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

27 Jul 2022

Abstract excerpt

We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (∆3678). The ∆3678 virus replicates about 7,500-fold lower than wild-type SARS-CoV-2 on primary human airway cultures, but restores its replication on interferon-deficient Vero-E6 cells that are approved for vaccine production. The ∆3678...

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PMID: 35896528
DOI: 10.1038/s41467-022-31930-z

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